[HTML][HTML] Overexpression of WISP-1 down-regulated motility and invasion of lung cancer cells through inhibition of Rac activation
LL Soon, TA Yie, A Shvarts, AJ Levine, F Su… - Journal of Biological …, 2003 - ASBMB
Wnt-induced-secreted-protein-1 (WISP-1) is a cysteine-rich, secreted factor belonging to the
CCN family. These proteins have been implicated in the inhibition of metastasis; however,
the mechanisms involved have not been described. We demonstrated that overexpression
of WISP-1 in H460 lung cancer cells inhibited lung metastasis and in vitro cell invasion and
motility. We investigated the possibility that WISP-1 may regulate activation of Rac, a small
GTPase important for cytoskeletal reorganizations during motility. In an indirect assay, WISP …
CCN family. These proteins have been implicated in the inhibition of metastasis; however,
the mechanisms involved have not been described. We demonstrated that overexpression
of WISP-1 in H460 lung cancer cells inhibited lung metastasis and in vitro cell invasion and
motility. We investigated the possibility that WISP-1 may regulate activation of Rac, a small
GTPase important for cytoskeletal reorganizations during motility. In an indirect assay, WISP …