[HTML][HTML] FISH analysis of gene aberrations (MYC, CCND1, ERBB2, RB, and AR) in advanced prostatic carcinomas before and after androgen deprivation therapy

C Kaltz-Wittmer, U Klenk, A Glaessgen, DE Aust… - Laboratory …, 2000 - Elsevier
Genetic mechanisms leading to androgen-independent growth in advanced prostatic
carcinomas (PC) are still poorly understood. Analysis of genes potentially involved in the
regulation of tumor cell proliferation and apoptosis might confer better insight into this
process and might lead to improved therapeutic strategies. Fluorescence in situ
hybridization (FISH) analysis of dissociated nuclei with DNA probes for MYC (8q24)/# 8,
cyclin D1 gene (CCND1; 11q13)/# 11, ERBB2 (17q13)/# 17, the androgen receptor gene …