Role of the high affinity immunoglobulin E receptor in bacterial translocation and intestinal inflammation

D Dombrowicz, S Nutten, P Desreumaux… - The Journal of …, 2001 - rupress.org
D Dombrowicz, S Nutten, P Desreumaux, C Neut, G Torpier, M Peeters, JF Colombel…
The Journal of experimental medicine, 2001rupress.org
A role for immunoglobulin E and its high affinity receptor (FcεRI) in the control of bacterial
pathogenicity and intestinal inflammation has been suggested, but relevant animal models
are lacking. Here we compare transgenic mice expressing a humanized FcεRI (hFcεRI), with
a cell distribution similar to that in humans, to FcεRI-deficient animals. In hFcεRI transgenic
mice, levels of colonic interleukin 4 were higher, the composition of fecal flora was greatly
modified, and bacterial translocation towards mesenteric lymph nodes was increased. In …
A role for immunoglobulin E and its high affinity receptor (FcεRI) in the control of bacterial pathogenicity and intestinal inflammation has been suggested, but relevant animal models are lacking. Here we compare transgenic mice expressing a humanized FcεRI (hFcεRI), with a cell distribution similar to that in humans, to FcεRI-deficient animals. In hFcεRI transgenic mice, levels of colonic interleukin 4 were higher, the composition of fecal flora was greatly modified, and bacterial translocation towards mesenteric lymph nodes was increased. In hFcεRI transgenic mice, 2,4,6-tri-nitrobenzenesulfonic acid (TNBS)-induced colitis was also more pronounced, whereas FcεRI-deficient animals were protected from colitis, demonstrating that FcεRI can affect the onset of intestinal inflammation.
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