Histamine was the first mediator implicated in mechanisms of allergy, asthma, and
anaphylactic shock because it has been discovered to mimic several features of these
diseases. In addition to its well-characterized effects in the acute inflammatory and allergic
responses, it was recently demonstrated that histamine regulates several essential events in
the immune response. Histamine affects the maturation of immune system cells and alters
their activation, polarization, chemotaxis, and effector functions. Histamine also regulates …