Regulation of Staphylococcus aureus type 5 capsular polysaccharides by agr and sarA in vitro and in an experimental endocarditis model
W van Wamel, YQ Xiong, A Bayer, M Yeaman… - Microbial …, 2002 - Elsevier
The expression of antiphagocytic polysaccharide capsules is an important pathogenetic step
in establishing Staphylococcus aureus infections. Using a green fluorescent protein reporter
gene (gfp) system, we examined the expression and genetic regulation of the cap5 promoter
(capsular polysaccharide 5 genes) by two major global regulators of S. aureus (agr and
sarA) in vitro and in a rabbit endocarditis model. In vitro, cap5 expression substantially
increased during the post-exponential phase in parental, as well assarA mutant constructs …
in establishing Staphylococcus aureus infections. Using a green fluorescent protein reporter
gene (gfp) system, we examined the expression and genetic regulation of the cap5 promoter
(capsular polysaccharide 5 genes) by two major global regulators of S. aureus (agr and
sarA) in vitro and in a rabbit endocarditis model. In vitro, cap5 expression substantially
increased during the post-exponential phase in parental, as well assarA mutant constructs …