Pituitary lineage determination by the Prophet of Pit-1 homeodomain factor defective in Ames dwarfism

MW Sornson, W Wu, JS Dasen, SE Flynn, DJ Norman… - Nature, 1996 - nature.com
MW Sornson, W Wu, JS Dasen, SE Flynn, DJ Norman, SM O'Connell, I Gukovsky, C Carrière…
Nature, 1996nature.com
The gene apparently responsible for a heritable form of murine pituitary-dependent dwarfism
(Ames dwarf, df) has been positionally cloned, identifying a novel, tissue-specific, paired-like
homeodomain transcription factor, termed Prophet of Pit-1 (Prop-1). The df phenotype
results from an apparent failure of initial determination of the Pit-1 lineage required for
production of growth hormone, prolactin or thyroid-stimulating hormone, resulting in
dysmorphogenesis and failure to activate Pit-1 gene expression. These results imply that a …
Abstract
The gene apparently responsible for a heritable form of murine pituitary-dependent dwarfism (Ames dwarf, df) has been positionally cloned, identifying a novel, tissue-specific, paired-like homeodomain transcription factor, termed Prophet of Pit-1 (Prop-1). The df phenotype results from an apparent failure of initial determination of the Pit-1 lineage required for production of growth hormone, prolactin or thyroid-stimulating hormone, resulting in dysmorphogenesis and failure to activate Pit-1 gene expression. These results imply that a cascade of tissue-specific regulators is responsible for the determination and differentiation of specific cell lineages in pituitary organogenesis.
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