Possible involvement of cytokines in diffuse intravascular coagulation and thrombosis
CT Esmon - Best Practice & Research Clinical Haematology, 1999 - Elsevier
Recently, basic and clinical advances have provided insights into the molecular events that
link inflammation with blood coagulation and thrombosis. At least in cell culture, the
inflammatory cytokines, especially tumour necrosis factor α (TNF) and interleukin 1-β (IL-1),
are major mediators that can elicit changes in cell phenotype. With respect to coagulation,
one of the clot-promoting and one of the inhibitory pathways seem especially prone to
modulation by these cytokines. Whenever Tissue Factor contacts the blood, coagulation is …
link inflammation with blood coagulation and thrombosis. At least in cell culture, the
inflammatory cytokines, especially tumour necrosis factor α (TNF) and interleukin 1-β (IL-1),
are major mediators that can elicit changes in cell phenotype. With respect to coagulation,
one of the clot-promoting and one of the inhibitory pathways seem especially prone to
modulation by these cytokines. Whenever Tissue Factor contacts the blood, coagulation is …