Time course and cellular localization of lipopolysaccharide-induced inducible nitric oxide synthase messenger RNA expression in the rat in vivo
SF Liu, PJ Barnes, TW Evans - Critical care medicine, 1997 - journals.lww.com
Objectives The role of nitric oxide in mediating the early phase of hypotension and
cardlovascular hyporeactivity in sepsis, and the cellular sources of inducible nitric oxide
synthase expression under in vivo conditions, remain unclear. The objective of this study
was to elucidate the time course and cellular location of inducible nitric oxide synthase
messenger RNA (mRNA) expression in rats treated with lipopolysaccharide in vivo. Design
cardlovascular hyporeactivity in sepsis, and the cellular sources of inducible nitric oxide
synthase expression under in vivo conditions, remain unclear. The objective of this study
was to elucidate the time course and cellular location of inducible nitric oxide synthase
messenger RNA (mRNA) expression in rats treated with lipopolysaccharide in vivo. Design