[PDF][PDF] IL-15Rα recycles and presents IL-15 in trans to neighboring cells
S Dubois, J Mariner, TA Waldmann, Y Tagaya - Immunity, 2002 - cell.com
S Dubois, J Mariner, TA Waldmann, Y Tagaya
Immunity, 2002•cell.comWe report intriguing aspects of the contribution of IL-15Rα to IL-15 functions. Consistent with
high-affinity interactions between IL-15 and IL-15Rα, these two molecules form stable
complexes on the cell surface of activated monocytes. The formation of IL-15/IL-15Rα
complexes on cell surfaces induces a trans-endosomal recycling of IL-15 leading to the
persistence of surface-bound IL-15 due to the constantreappearance of IL-15 on plasma
membranes. This complex contributes to the long survival of T cells expressing IL-15Rα after …
high-affinity interactions between IL-15 and IL-15Rα, these two molecules form stable
complexes on the cell surface of activated monocytes. The formation of IL-15/IL-15Rα
complexes on cell surfaces induces a trans-endosomal recycling of IL-15 leading to the
persistence of surface-bound IL-15 due to the constantreappearance of IL-15 on plasma
membranes. This complex contributes to the long survival of T cells expressing IL-15Rα after …
Abstract
We report intriguing aspects of the contribution of IL-15Rα to IL-15 functions. Consistent with high-affinity interactions between IL-15 and IL-15Rα, these two molecules form stable complexes on the cell surface of activated monocytes. The formation of IL-15/IL-15Rα complexes on cell surfaces induces a trans-endosomal recycling of IL-15 leading to the persistence of surface-bound IL-15 due to the constantreappearance of IL-15 on plasma membranes. This complex contributes to the long survival of T cells expressing IL-15Rα after IL-15 withdrawal. Finally, these complexes on activated monocytes present IL-15 in trans to target cells such as CD8+ T cells that express only IL-2/15Rβ and γc upon cell-cell interaction.
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