Storage and release of tissue plasminogen activator by sympathetic axons in resistance vessel walls
X Jiang, Y Wang, AR Hand, C Gillies, RE Cone… - Microvascular …, 2002 - Elsevier
We studied the immunolocalization of tissue plasminogen activator (t-PA) in rat precapillary
arteries, arterioles, and terminal arterioles. Lack of information about the precise location of t-
PA within small vessel walls has contributed to uncertainty about its cellular source. The
presumed origin has been an endothelial phenotype largely restricted to certain small
vessels. However, vessel wall sympathetic axons were recently also shown to store
significant amounts of a neuron-generated t-PA in secretory vesicles. Using …
arteries, arterioles, and terminal arterioles. Lack of information about the precise location of t-
PA within small vessel walls has contributed to uncertainty about its cellular source. The
presumed origin has been an endothelial phenotype largely restricted to certain small
vessels. However, vessel wall sympathetic axons were recently also shown to store
significant amounts of a neuron-generated t-PA in secretory vesicles. Using …