[HTML][HTML] The low density lipoprotein receptor-related protein modulates levels of matrix metalloproteinase 9 (MMP-9) by mediating its cellular catabolism
E Hahn-Dantona, JF Ruiz, P Bornstein… - Journal of Biological …, 2001 - ASBMB
Members of the matrix metalloproteinase (MMP) family of enzymes participate in matrix
remodeling and share a number of structural and functional features. The activity of this
family of proteinases is carefully regulated at the level of zymogen activation and by a family
of specific inhibitors termed tissue inhibitors of metalloproteinases (TIMP). It is now
becoming clear that levels of certain MMPs are modulated by their association with cellular
receptors that mediate their rapid internalization and degradation. In the current …
remodeling and share a number of structural and functional features. The activity of this
family of proteinases is carefully regulated at the level of zymogen activation and by a family
of specific inhibitors termed tissue inhibitors of metalloproteinases (TIMP). It is now
becoming clear that levels of certain MMPs are modulated by their association with cellular
receptors that mediate their rapid internalization and degradation. In the current …