[HTML][HTML] Elucidation of Smad requirement in transforming growth factor-β type I receptor-induced responses
S Itoh, M Thorikay, M Kowanetz, A Moustakas… - Journal of Biological …, 2003 - ASBMB
Transforming growth factor-β (TGF-β) elicits cellular effects by activating specific Smad
proteins that control the transcription of target genes. Whereas there is growing evidence
that there are TGF-β type I receptor-initiated intracellular pathways that are distinct from the
pivotal Smad pathway, their physiological importance in TGF-β signaling is not well
understood. Therefore, we generated TGF-β type I receptors (also termed ALK5s) with
mutations in the L45 loop of the kinase domain, termed ALK5 (D266A) and ALK5 (3A) …
proteins that control the transcription of target genes. Whereas there is growing evidence
that there are TGF-β type I receptor-initiated intracellular pathways that are distinct from the
pivotal Smad pathway, their physiological importance in TGF-β signaling is not well
understood. Therefore, we generated TGF-β type I receptors (also termed ALK5s) with
mutations in the L45 loop of the kinase domain, termed ALK5 (D266A) and ALK5 (3A) …