[HTML][HTML] Phosphatidylinositol 3-kinase interacts with the adaptor protein Dab1 in response to Reelin signaling and is required for normal cortical lamination
Reelin is a large secreted signaling protein that binds to two members of the low density
lipoprotein receptor family, the apolipoprotein E receptor 2 and the very low density
lipoprotein receptor, and regulates neuronal positioning during brain development. Reelin
signaling requires activation of Src family kinases as well as tyrosine phosphorylation of the
intracellular adaptor protein Disabled-1 (Dab1). This results in activation of
phosphatidylinositol 3-kinase (PI3K), the serine/threonine kinase Akt, and the inhibition of …
lipoprotein receptor family, the apolipoprotein E receptor 2 and the very low density
lipoprotein receptor, and regulates neuronal positioning during brain development. Reelin
signaling requires activation of Src family kinases as well as tyrosine phosphorylation of the
intracellular adaptor protein Disabled-1 (Dab1). This results in activation of
phosphatidylinositol 3-kinase (PI3K), the serine/threonine kinase Akt, and the inhibition of …