The low density lipoprotein (LDL) receptor-related protein (LRP) is a multifunctional cell
surface receptor that interacts through its cytoplasmic tail with adaptor and scaffold proteins
that participate in cellular signaling. Its extracellular domain, like that of the signaling
receptor Notch and of amyloid precursor protein (APP), is proteolytically processed at
multiple positions. This similarity led us to investigate whether LRP, like APP and Notch,
might also be cleaved at a third, intramembranous or cytoplasmic site, resulting in the …