Lipoprotein receptors, such as LRP, have been shown to assemble multiprotein complexes
containing intracellular signaling molecules; however, in vivo, their signaling function is
poorly understood. Using a novel LRP receptor fusion construct, a type I transmembrane
protein chimera, termed sIgG-LRP (bearing the intracellular COOH-terminal tail of human
LRP as recombinant fusion to a transmembrane region plus the extracellular IgG-F c
domain), we here investigated LRP signal transduction specificity in intact cells. First and …