Influence of CD26 and integrins on the antigen sensitivity of human memory T cells
F Falcioni, H Shah, D Vidović, C Morimoto, C Belunis… - Human immunology, 1996 - Elsevier
The antigen sensitivity of class II MHC-restricted human CD4 T-cell clones is demonstrated
to increase gradually with time after restimulation. This is manifested in a requirement of less
antigen in culture, as well as decreased numbers of peptide-MHC complexes per APC for T-
cell activation, and in an increased resistance to inhibition by class II MHC blockade. The
increase in antigen sensitivity is accompanied by increased cellsurface expression of CD26,
LFA-1, and VLA-1, whereas the expression of TCR and a series of other cell-surface …
to increase gradually with time after restimulation. This is manifested in a requirement of less
antigen in culture, as well as decreased numbers of peptide-MHC complexes per APC for T-
cell activation, and in an increased resistance to inhibition by class II MHC blockade. The
increase in antigen sensitivity is accompanied by increased cellsurface expression of CD26,
LFA-1, and VLA-1, whereas the expression of TCR and a series of other cell-surface …