[HTML][HTML] Scurfin (FOXP3) acts as a repressor of transcription and regulates T cell activation
LA Schubert, E Jeffery, Y Zhang, F Ramsdell… - Journal of Biological …, 2001 - ASBMB
We have recently identified and clonedFoxp3, the gene defective in mice with thescurfy
mutation. The immune dysregulation documented in these mice and in humans with
mutations in the orthologous gene indicates that the foxp3 gene product, scurfin, is involved
in the regulation of T cell activation and differentiation. The autoimmune state observed in
these patients with the immune dysregulation polyendocrinopathy, enteropathy, X-linked
syndrome, or X-linked autoimmunity-allergic dysregulation syndrome also points to a critical …
mutation. The immune dysregulation documented in these mice and in humans with
mutations in the orthologous gene indicates that the foxp3 gene product, scurfin, is involved
in the regulation of T cell activation and differentiation. The autoimmune state observed in
these patients with the immune dysregulation polyendocrinopathy, enteropathy, X-linked
syndrome, or X-linked autoimmunity-allergic dysregulation syndrome also points to a critical …