Tumor necrosis factor primes hepatocytes for DNA replication in the rat
EM Webber, J Bruix, RH Pierce, N Fausto - Hepatology, 1998 - journals.lww.com
Signaling through tumor necrosis factor receptor type 1 (TNFR–1) using a pathway that
involves nuclear factor κB (NF–κB), interleukin–6 (IL–6), and STAT3 is required for the
initiation of liver regeneration. We have proposed that TNF primes hepatocytes to respond to
the mitogenic effect of growth factors, but so far, there has been no experimental
demonstration that TNF enhances growth factor responses of hepatocytes. To test this
hypothesis, we infused hepatocyte growth factor (HGF) and transforming growth factor α …
involves nuclear factor κB (NF–κB), interleukin–6 (IL–6), and STAT3 is required for the
initiation of liver regeneration. We have proposed that TNF primes hepatocytes to respond to
the mitogenic effect of growth factors, but so far, there has been no experimental
demonstration that TNF enhances growth factor responses of hepatocytes. To test this
hypothesis, we infused hepatocyte growth factor (HGF) and transforming growth factor α …