[HTML][HTML] Direct association with thioredoxin allows redox regulation of glucocorticoid receptor function
Y Makino, N Yoshikawa, K Okamoto, K Hirota… - Journal of Biological …, 1999 - ASBMB
The glucocorticoid receptor (GR) is considered to belong to a class of transcription factors,
the functions of which are exposed to redox regulation. We have recently demonstrated that
thioredoxin (TRX), a cellular reducing catalyst, plays an important role in restoration of GR
function in vivo under oxidative conditions. Although both the ligand binding domain and
other domains of the GR have been suggested to be modulated by TRX, the molecular
mechanism of the interaction is largely unknown. In the present study, we hypothesized that …
the functions of which are exposed to redox regulation. We have recently demonstrated that
thioredoxin (TRX), a cellular reducing catalyst, plays an important role in restoration of GR
function in vivo under oxidative conditions. Although both the ligand binding domain and
other domains of the GR have been suggested to be modulated by TRX, the molecular
mechanism of the interaction is largely unknown. In the present study, we hypothesized that …