[HTML][HTML] Distinct roles of thioredoxin in the cytoplasm and in the nucleus: a two-step mechanism of redox regulation of transcription factor NF-κB
K Hirota, M Murata, Y Sachi, H Nakamura… - Journal of Biological …, 1999 - ASBMB
Oxidative stresses such as UV irradiation to mammalian cells triggers a variety of oxistress
responses including activation of transcription factors. Recently, activation of nuclear factor-
κB (NF-κB) has been shown to be under oxidoreduction (redox) regulation controlled by
thioredoxin (TRX), which is one of major endogenous redox-regulating molecules with thiol
reducing activity. In order to elucidate where in the cellular compartment TRX participates in
NF-κB regulation, we investigated the intracellular localization of TRX. UVB irradiation …
responses including activation of transcription factors. Recently, activation of nuclear factor-
κB (NF-κB) has been shown to be under oxidoreduction (redox) regulation controlled by
thioredoxin (TRX), which is one of major endogenous redox-regulating molecules with thiol
reducing activity. In order to elucidate where in the cellular compartment TRX participates in
NF-κB regulation, we investigated the intracellular localization of TRX. UVB irradiation …