Oxidative stress is associated with liver fibrosis and with hepatic stellate cell (HSC)
activation in vivo. However, it remains controversial whether oxidative stress contributes to
HSC activation either directly or through a paracrine stimulation by damaged hepatocytes. A
medium containing products released from cells undergoing oxidative stress was obtained
after incubation of hepatocytes with (HCM/Fe) or without (HCM) 0.1 mmol/L ferric
nitrilotriacetate complex (FeNTA). Exposure of HSC to HCM/Fe for 24 hours significantly …