Structure of the skin barrier and its modulation by vesicular formulations

JA Bouwstra, PL Honeywell-Nguyen, GS Gooris… - Progress in lipid …, 2003 - Elsevier
The natural function of the skin is to protect the body from unwanted influences from the
environment. The main barrier of the skin is located in the outermost layer of the skin, the
stratum corneum. Since the lipids regions in the stratum corneum form the only continuous
structure, substances applied onto the skin always have to pass these regions. For this
reason the organization in the lipid domains is considered to be very important for the skin
barrier function. Due to the exceptional stratum corneum lipid composition, with long chain …