[HTML][HTML] Role of ceramide 1 in the molecular organization of the stratum corneum lipids
JA Bouwstra, GS Gooris, FER Dubbelaar… - Journal of lipid …, 1998 - ASBMB
The main barrier of the skin is formed by the lipids in the apical skin layer, the stratum
corneum (SC). In SC mainly ceramides (CER), free fatty acids (FFA) and cholesterol (CHOL)
are present. The CER are composed of at least six different fractions. CER 1 has an
exceptional molecular structure as it contains a linoleic acid linked to a long-chain ω-
hydroxy acid (C> 30). The SC lipids are organized in two lamellar phases with periodicities
of approximately 6 and 13 nm, respectively. Recent studies revealed that ceramides isolated …
corneum (SC). In SC mainly ceramides (CER), free fatty acids (FFA) and cholesterol (CHOL)
are present. The CER are composed of at least six different fractions. CER 1 has an
exceptional molecular structure as it contains a linoleic acid linked to a long-chain ω-
hydroxy acid (C> 30). The SC lipids are organized in two lamellar phases with periodicities
of approximately 6 and 13 nm, respectively. Recent studies revealed that ceramides isolated …