[HTML][HTML] Sphingolipid activator proteins are required for epidermal permeability barrier formation
T Doering, WM Holleran, A Potratz, G Vielhaber… - Journal of Biological …, 1999 - ASBMB
The epidermal permeability barrier is maintained by extracellular lipid membranes within the
interstices of the stratum corneum. Ceramides, the major components of these multilayered
membranes, derive in large part from hydrolysis of glucosylceramides mediated by stratum
corneum β-glucocerebrosidase (β-GlcCerase). Prosaposin (pSAP) is a large precursor
protein that is proteolytically cleaved to form four distinct sphingolipid activator proteins,
which stimulate enzymatic hydrolysis of sphingolipids, including glucosylceramide …
interstices of the stratum corneum. Ceramides, the major components of these multilayered
membranes, derive in large part from hydrolysis of glucosylceramides mediated by stratum
corneum β-glucocerebrosidase (β-GlcCerase). Prosaposin (pSAP) is a large precursor
protein that is proteolytically cleaved to form four distinct sphingolipid activator proteins,
which stimulate enzymatic hydrolysis of sphingolipids, including glucosylceramide …