[HTML][HTML] Tumor-derived osteopontin is soluble, not matrix associated
SR Rittling, Y Chen, F Feng, Y Wu - Journal of Biological Chemistry, 2002 - ASBMB
The secreted phosphoprotein osteopontin (OPN), when immobilized on a surface, supports
cell adhesion, prevents apoptosis of endothelial cells, and is a ligand for the α v β 3 integrin,
which is important in endothelial cell biology and neovascularization. OPN synthesized by
tumor cells stimulates tumor growth, but the mechanism by which the protein acts remains
unclear. One possibility, therefore, is that OPN may exert its effects on tumor growth by
enhancing angiogenesis. While OPN is found at high levels in bone, where it is a …
cell adhesion, prevents apoptosis of endothelial cells, and is a ligand for the α v β 3 integrin,
which is important in endothelial cell biology and neovascularization. OPN synthesized by
tumor cells stimulates tumor growth, but the mechanism by which the protein acts remains
unclear. One possibility, therefore, is that OPN may exert its effects on tumor growth by
enhancing angiogenesis. While OPN is found at high levels in bone, where it is a …