The elastin gene is disrupted by a translocation associated with supravalvular aortic stenosis

ME Curran, DL Atkinson, AK Ewart, CA Morris… - Cell, 1993 - cell.com
ME Curran, DL Atkinson, AK Ewart, CA Morris, MF Leppert, MT Keating
Cell, 1993cell.com
To identify genes involved in vascular disease, we investigated patients with supravalvular
aortlc stenosis (SVAS), an inherited vascular disorder that causes hemodynamically
significant narrowing of large elastic arteries. Pulsed-field gel and Southern analyses
showed that a translocation near the elastin gene cosegregated with SVAS in one family.
DNA sequence analyses demonstrated that the translocation disrupted the elastin gene and
localized the breakpoint to exon 28. Taken together with our previous study linking SVAS to …
Summary
To identify genes involved in vascular disease, we investigated patients with supravalvular aortlc stenosis (SVAS), an inherited vascular disorder that causes hemodynamically significant narrowing of large elastic arteries. Pulsed-field gel and Southern analyses showed that a translocation near the elastin gene cosegregated with SVAS in one family. DNA sequence analyses demonstrated that the translocation disrupted the elastin gene and localized the breakpoint to exon 28. Taken together with our previous study linking SVAS to the elastin gene in two additional families and existing knowledge of vascular biology, these data suggest that mutations in the elastin gene can cause SVAS.
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