The developing heart and congenital heart defects: a make or break situation
BG Bruneau - Clinical genetics, 2003 - Wiley Online Library
Clinical genetics, 2003•Wiley Online Library
Congenital heart defects are common in humans, but the underlying basis for these defects
is not well understood. It has been clear that abnormal heart development is at the root of
these diseases, but the genes involved have remained elusive until recently. This review
focuses on recent advances in our understanding of mammalian heart formation, and how
some of these processes, when disrupted, lead to congenital heart defects.
is not well understood. It has been clear that abnormal heart development is at the root of
these diseases, but the genes involved have remained elusive until recently. This review
focuses on recent advances in our understanding of mammalian heart formation, and how
some of these processes, when disrupted, lead to congenital heart defects.
Congenital heart defects are common in humans, but the underlying basis for these defects is not well understood. It has been clear that abnormal heart development is at the root of these diseases, but the genes involved have remained elusive until recently. This review focuses on recent advances in our understanding of mammalian heart formation, and how some of these processes, when disrupted, lead to congenital heart defects.
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