[HTML][HTML] Bacterial lipopolysaccharide activates NF-κB through toll-like receptor 4 (TLR-4) in cultured human dermal endothelial cells: differential expression of TLR-4 …
E Faure, O Equils, PA Sieling, L Thomas… - Journal of Biological …, 2000 - ASBMB
A missense mutation in the cytoplasmic domain of the Toll-like receptor-4 (TLR-4) has been
identified as the defect responsible for lipopolysaccharide (LPS) hyporesponsiveness in
C3H/HeJ mice. TLR-4 and TLR-2 have recently been implicated in LPS signaling in studies
where these receptors were overexpressed in LPS non-responsive 293 human embryonic
kidney cells. However, the signaling role of TLR-4 or TLR-2 in human cells with natural LPS
response remains largely undefined. Here we show that human dermal microvessel …
identified as the defect responsible for lipopolysaccharide (LPS) hyporesponsiveness in
C3H/HeJ mice. TLR-4 and TLR-2 have recently been implicated in LPS signaling in studies
where these receptors were overexpressed in LPS non-responsive 293 human embryonic
kidney cells. However, the signaling role of TLR-4 or TLR-2 in human cells with natural LPS
response remains largely undefined. Here we show that human dermal microvessel …