TIRAP: how Toll receptors fraternize
P Henneke, DT Golenbock - Nature immunology, 2001 - nature.com
Nature immunology, 2001•nature.com
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Although some cellular responses induced by TLRs are abolished in MyD88-deficient mice, TLR4, unlike TLR9, can still induce activation of NF-κB and MAPKs. The discovery of a cytoplasmic adapter protein for TLR4, called TIRAP, helps explain this phenomenon.
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