Cutting edge: anti-CD1 monoclonal antibody treatment reverses the production patterns of TGF-β2 and Th1 cytokines and ameliorates listeriosis in mice

G Szalay, CH Ladel, C Blum, L Brossay… - The Journal of …, 1999 - journals.aai.org
G Szalay, CH Ladel, C Blum, L Brossay, M Kronenberg, SHE Kaufmann
The Journal of Immunology, 1999journals.aai.org
Protection against intracellular bacteria by T cells is regulated by Ag-presenting molecules,
which comprise classical MHC class I molecules, MHC class II molecules, and nonclassical
MHC class Ib molecules. The role of CD1 molecules, which are structurally similar to
classical MHC class I gene products, but less polymorphic, is not understood so far. We
show that CD1 surface expression increased on APC in Listeria-infected mice. The in vivo
treatment with anti-CD1 mAb reduced TGF-β2 levels and concomitantly increased secretion …
Abstract
Protection against intracellular bacteria by T cells is regulated by Ag-presenting molecules, which comprise classical MHC class I molecules, MHC class II molecules, and nonclassical MHC class Ib molecules. The role of CD1 molecules, which are structurally similar to classical MHC class I gene products, but less polymorphic, is not understood so far. We show that CD1 surface expression increased on APC in Listeria-infected mice. The in vivo treatment with anti-CD1 mAb reduced TGF-β2 levels and concomitantly increased secretion of the proinflammatory cytokine TNF, the Th1 cell promoting cytokine IL-12, and the Th1 cell cytokine IFN-γ at the onset of listerial infection. These findings point to a regulatory role of CD1-reactive cells in the immune response against listeriosis.
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