Publisher Summary This chapter focuses on the molecular mechanisms of switch
recombination and other possible modes of isotype switching. It discusses the regulation of
isotype switching, especially by T cells and the cytokines they produce. Virtually all of the
analyses of the mechanisms and regulation of switching are done in either mouse or human,
with a disproportionate amount done in the mouse. The two species are discussed
separately, although the basic lessons learned from the mouse are, for the most part, valid …