Interferon-γ and B cell stimulatory factor-1 reciprocally regulate Ig isotype production
CM Snapper, WE Paul - Science, 1987 - science.org
CM Snapper, WE Paul
Science, 1987•science.orgGamma interferon (IFN-γ) and B cell stimulatory factor-1 (BSF-1), also known as interleukin-
4, are T cell-derived lymphokines that have potent effects on B cell proliferation and
differentiation. They are often secreted by distinct T cell clones. It is now shown that IFN-γ
stimulates the expression of immunoglobulin (Ig) of the IgG2a isotype and inhibits the
production of IgG3, IgG1, IgG2b, and IgE. By contrast, BSF-1 has powerful effects in
promoting switching to the expression of IgG1 and IgE but markedly inhibits IgM, IgG3 …
4, are T cell-derived lymphokines that have potent effects on B cell proliferation and
differentiation. They are often secreted by distinct T cell clones. It is now shown that IFN-γ
stimulates the expression of immunoglobulin (Ig) of the IgG2a isotype and inhibits the
production of IgG3, IgG1, IgG2b, and IgE. By contrast, BSF-1 has powerful effects in
promoting switching to the expression of IgG1 and IgE but markedly inhibits IgM, IgG3 …
Gamma interferon (IFN-γ) and B cell stimulatory factor-1 (BSF-1), also known as interleukin-4, are T cell-derived lymphokines that have potent effects on B cell proliferation and differentiation. They are often secreted by distinct T cell clones. It is now shown that IFN-γ stimulates the expression of immunoglobulin (Ig) of the IgG2a isotype and inhibits the production of IgG3, IgG1, IgG2b, and IgE. By contrast, BSF-1 has powerful effects in promoting switching to the expression of IgG1 and IgE but markedly inhibits IgM, IgG3, IgG2a, and IgG2b. These results indicate that BSF-1 and IFN-γ as well as the T cells that produce them may act as reciprocal regulatory agents in the determination of Ig isotype responses. The effects of IFN-γ and BSF-1 on isotype expression are independent.
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