Involvement of interleukin-6 in atherosclerosis but not in the prevention of fatty streak formation by 17β-estradiol in apolipoprotein E-deficient mice
R Elhage, S Clamens, S Besnard, Z Mallat, A Tedgui… - Atherosclerosis, 2001 - Elsevier
Interleukin-6 (IL-6) gene expressed in bone marrow-derived stromal cells and osteoblasts
contributes to the state of mineralization and its control by estradiol may be involved in the
development of post-menopausal osteoporosis. Since IL-6 is also expressed in the different
cell populations of the arterial wall, the purpose of this study was to gain more insight into its
involvement in the atherosclerotic process and the atheroprotective effect of estradiol by
studying double deficient mice at the apolipoprotein E and IL-6 loci (IL-6−/−/E−/−). At 1 year …
contributes to the state of mineralization and its control by estradiol may be involved in the
development of post-menopausal osteoporosis. Since IL-6 is also expressed in the different
cell populations of the arterial wall, the purpose of this study was to gain more insight into its
involvement in the atherosclerotic process and the atheroprotective effect of estradiol by
studying double deficient mice at the apolipoprotein E and IL-6 loci (IL-6−/−/E−/−). At 1 year …