As the intestine is an essential organ for fish osmoregulation, the intestinal hormone
guanylins may perform major functions, especially in euryhaline fish such as eels and
salmonids. From the intestine of an eel, we identified cDNAs encoding three distinct
guanylin-like peptides. Based on the sequence of mature peptide and sites of production,
we named them guanylin, uroguanylin, and renoguanylin. Renoguanylin is a novel peptide
that possesses the characteristics of both guanylin and uroguanylin and was abundantly …