[HTML][HTML] Guanylin, uroguanylin, and heat-stable euterotoxin activate guanylate cyclase C and/or a pertussis toxin-sensitive G protein in human proximal tubule cells
A Sindiće, C Başoglu, A Cerçi, JR Hirsch… - Journal of Biological …, 2002 - ASBMB
Membrane guanylate cyclase C (GC-C) is the receptor for guanylin, uroguanylin, and heat-
stable enterotoxin (STa) in the intestine. GC-C-deficient mice show resistance to STa in
intestine but saluretic and diuretic effects of uroguanylin and STa are not disturbed. Here we
describe the cellular effects of these peptides using immortalized human kidney epithelial
(IHKE-1) cells with properties of the proximal tubule, analyzed with the slow-whole-cell patch
clamp technique. Uroguanylin (10 or 100 nm) either hyperpolarized or depolarized …
stable enterotoxin (STa) in the intestine. GC-C-deficient mice show resistance to STa in
intestine but saluretic and diuretic effects of uroguanylin and STa are not disturbed. Here we
describe the cellular effects of these peptides using immortalized human kidney epithelial
(IHKE-1) cells with properties of the proximal tubule, analyzed with the slow-whole-cell patch
clamp technique. Uroguanylin (10 or 100 nm) either hyperpolarized or depolarized …