[HTML][HTML] Ischemia-induced STAT-1 expression and activation play a critical role in cardiomyocyte apoptosis
A Stephanou, BK Brar, TM Scarabelli… - Journal of Biological …, 2000 - ASBMB
We show here that exposure of cardiac cells to simulated ischemia results in apoptosis and
is accompanied by phosphorylation and increased expression and transcriptional activity of
STAT-1. Similarly, interferon-γ, which is known to induce STAT-1 activation, also induced
apoptosis in cardiac cells. STAT-1-transfected cells were more susceptible to ischemia-
induced cell death than cells transfected with a control plasmid lacking the STAT-1 coding
sequence. Furthermore, an antisense STAT-1 vector reduced both ischemia-and …
is accompanied by phosphorylation and increased expression and transcriptional activity of
STAT-1. Similarly, interferon-γ, which is known to induce STAT-1 activation, also induced
apoptosis in cardiac cells. STAT-1-transfected cells were more susceptible to ischemia-
induced cell death than cells transfected with a control plasmid lacking the STAT-1 coding
sequence. Furthermore, an antisense STAT-1 vector reduced both ischemia-and …