A critical role for NF-κB transcription factors in the development of CD8+ memory-phenotype T cells
T Hettmann, JT Opferman, JM Leiden… - Immunology letters, 2003 - Elsevier
Memory T cells are essential for generating secondary immune responses and so provide
long-lived protection from pathogens. The mechanisms that regulate the differentiation and
survival of memory T cells are largely unknown. Transgenic mice in which NF-κB activity is
inhibited by the expression of a dominant-negative form of IκB-α (mIκB-α mice) have
drastically diminished numbers of CD8+ memory-phenotype cells. The development of
activated mIκB-α CD8 cells into memory-phenotype CD8 cells was severely impaired after …
long-lived protection from pathogens. The mechanisms that regulate the differentiation and
survival of memory T cells are largely unknown. Transgenic mice in which NF-κB activity is
inhibited by the expression of a dominant-negative form of IκB-α (mIκB-α mice) have
drastically diminished numbers of CD8+ memory-phenotype cells. The development of
activated mIκB-α CD8 cells into memory-phenotype CD8 cells was severely impaired after …