[HTML][HTML] Interleukin-1β-induced Ceramide and Diacylglycerol Generation 5 Lead to Activation of the c-Jun NH2-terminal Kinase and the Transcription Factor ATF2 in …
N Welsh - Journal of biological chemistry, 1996 - ASBMB
The aim of this investigation was to study the putative involvement of lipid second
messengers, protein kinases, and transcription factors in interleukin-1β (IL-1β)-induced
signal transduction in insulin-producing cells. For this purpose, insulin-producing RINm5F
cells were exposed to IL-1β (25 units/ml), and the ceramide, ceramide 1-phosphate,
sphingomyelin, diacylglycerol, and phosphatidic acid contents of the cells were
subsequently determined. It was found that IL-1β induced a transient increase (2-5 min) in …
messengers, protein kinases, and transcription factors in interleukin-1β (IL-1β)-induced
signal transduction in insulin-producing cells. For this purpose, insulin-producing RINm5F
cells were exposed to IL-1β (25 units/ml), and the ceramide, ceramide 1-phosphate,
sphingomyelin, diacylglycerol, and phosphatidic acid contents of the cells were
subsequently determined. It was found that IL-1β induced a transient increase (2-5 min) in …