[HTML][HTML] Gravin-mediated formation of signaling complexes in β2-adrenergic receptor desensitization and resensitization
F Lin, H Wang, CC Malbon - Journal of Biological Chemistry, 2000 - ASBMB
Agonist-induced desensitization and resensitization of G-protein-linked receptors involve the
interaction of receptors with protein kinases, phosphatases, β-arrestin, and clathrin
organized by at least one scaffold protein. The dynamic composition of the signaling
complexes and the role of the scaffold protein AKAP250 (gravin) in agonist-induced
attenuation and recovery of β-adrenergic receptors were explored by co-
immunoprecipitation of target elements, antisense suppression, and confocal microscopy …
interaction of receptors with protein kinases, phosphatases, β-arrestin, and clathrin
organized by at least one scaffold protein. The dynamic composition of the signaling
complexes and the role of the scaffold protein AKAP250 (gravin) in agonist-induced
attenuation and recovery of β-adrenergic receptors were explored by co-
immunoprecipitation of target elements, antisense suppression, and confocal microscopy …