Alteration of intracellular structure and function of glyceraldehyde-3-phosphate dehydrogenase: a common phenotype of neurodegenerative disorders?
JL Mazzola, MA Sirover - Neurotoxicology, 2002 - Elsevier
Recent evidence reveals that glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is not
simply a classical glycolytic protein of little interest. Instead, it is a multifunctional protein with
diverse cytoplasmic, membrane and nuclear activities. Significantly, each activity is separate
and distinct from its role in energy production. Its nuclear activities include its emerging role
in apoptosis especially in neuronal cells. GAPDH translocates into the nucleus during
programmed cell death. Introduction of antisense GAPDH sequences reduces apoptosis …
simply a classical glycolytic protein of little interest. Instead, it is a multifunctional protein with
diverse cytoplasmic, membrane and nuclear activities. Significantly, each activity is separate
and distinct from its role in energy production. Its nuclear activities include its emerging role
in apoptosis especially in neuronal cells. GAPDH translocates into the nucleus during
programmed cell death. Introduction of antisense GAPDH sequences reduces apoptosis …