Novel phenanthridinone inhibitors of poly (adenosine 5′-diphosphate-ribose) synthetase: potent cytoprotective and antishock agents
P Jagtap, FG Soriano, L Virág, L Liaudet… - Critical care …, 2002 - journals.lww.com
Objective To synthesize novel inhibitors of the nuclear enzyme poly (adenosine 5′-
diphosphate [ADP]-ribose) synthetase (PARS), also known as poly (ADP-ribose)
polymerase (PARP), and to test them in in vitro models of oxidant-induced cytotoxicity and in
endotoxin and splanchnic occlusion-reperfusion-induced shock. Design
diphosphate [ADP]-ribose) synthetase (PARS), also known as poly (ADP-ribose)
polymerase (PARP), and to test them in in vitro models of oxidant-induced cytotoxicity and in
endotoxin and splanchnic occlusion-reperfusion-induced shock. Design