Induction of persistently demyelinated lesions in the rat following the repeated adoptive transfer of encephalitogenic T cells and demyelinating antibody
C Linington, B Engelhardt, G Kapocs… - Journal of …, 1992 - Elsevier
A chronic relapsing model of demyelinating experimental allergic encephalomyelitis (EAE)
was induced in Lewis rats by the repeated co-transfer of encephalitogenic, myelin basic
protein (MBP)-specific T cells in combination with a demyelinating monoclonal antibody
(mAb) specific for the myelin oligodendrocyte glycoprotein (MOG). In controls, repeated
injections of 5× 10 5 MBP-specific T cells at intervals of 18–21 days resulted in an increasing
resistance to the induction of further episodes of EAE. However, intravenous injection of the …
was induced in Lewis rats by the repeated co-transfer of encephalitogenic, myelin basic
protein (MBP)-specific T cells in combination with a demyelinating monoclonal antibody
(mAb) specific for the myelin oligodendrocyte glycoprotein (MOG). In controls, repeated
injections of 5× 10 5 MBP-specific T cells at intervals of 18–21 days resulted in an increasing
resistance to the induction of further episodes of EAE. However, intravenous injection of the …