The nuclear receptor PPARγ is a central regulator of adipose tissue development and an
important modulator of gene expression in a number of specialized cell types including
adipocytes, epithelial cells, and macrophages. PPARγ signaling pathways impact both
cellular and systemic lipid metabolism and have links to obesity, diabetes, and
cardiovascular disease. The ability to activate this receptor with small molecule ligands has
made PPARγ an attractive target for intervention in human metabolic disease. As our …