[HTML][HTML] Peroxisome proliferator-activated receptors α and γ are activated by indomethacin and other non-steroidal anti-inflammatory drugs
JM Lehmann, JM Lenhard, BB Oliver… - Journal of Biological …, 1997 - ASBMB
Indomethacin is a non-steroidal anti-inflammatory drug (NSAID) and cyclooxygenase
inhibitor that is frequently used as a research tool to study the process of adipocyte
differentiation. Treatment of various preadipocyte cell lines with micromolar concentrations
of indomethacin in the presence of insulin promotes their terminal differentiation. However,
the molecular basis for the adipogenic actions of indomethacin had remained unclear. In this
report, we show that indomethacin binds and activates peroxisome proliferator-activated …
inhibitor that is frequently used as a research tool to study the process of adipocyte
differentiation. Treatment of various preadipocyte cell lines with micromolar concentrations
of indomethacin in the presence of insulin promotes their terminal differentiation. However,
the molecular basis for the adipogenic actions of indomethacin had remained unclear. In this
report, we show that indomethacin binds and activates peroxisome proliferator-activated …