[HTML][HTML] Transcriptional mechanisms of bone morphogenetic protein-induced osteoprotegrin gene expression
Osteoprotegerin (OPG), an osteoblast-secreted decoy receptor, specifically binds to
osteoclast differentiation factor and inhibits osteoclast maturation. Members of the
transforming growth factor-β superfamily including bone morphogenetic proteins (BMPs)
stimulate OPG mRNA expression. In this study, we have characterized the transcription
mechanism of BMP-induced OPG gene expression. Transfection of Smad1 and a
constitutively active BMP type IA receptor ALK3 (Q233) stimulated the OPG promoter …
osteoclast differentiation factor and inhibits osteoclast maturation. Members of the
transforming growth factor-β superfamily including bone morphogenetic proteins (BMPs)
stimulate OPG mRNA expression. In this study, we have characterized the transcription
mechanism of BMP-induced OPG gene expression. Transfection of Smad1 and a
constitutively active BMP type IA receptor ALK3 (Q233) stimulated the OPG promoter …