[HTML][HTML] Estrogen decreases osteoclast formation by down-regulating receptor activator of NF-κB ligand (RANKL)-induced JNK activation
S Srivastava, G Toraldo, MN Weitzmann… - Journal of Biological …, 2001 - ASBMB
The differentiation of cells of the monocytic lineage into mature osteoclasts (OC) is
specifically induced by the tumor necrosis factor-related factor, RANKL (receptor activator of
NF-κB ligand; also known as OPGL, ODF, or TRANCE). Because inhibition of
osteoclastogenesis is one of the main mechanisms by which estrogen (E2) prevents bone
loss, it is likely that E2 may regulate either the production of, or the target cell
responsiveness to RANKL. We found that E2 decreases the differentiation into OC of both …
specifically induced by the tumor necrosis factor-related factor, RANKL (receptor activator of
NF-κB ligand; also known as OPGL, ODF, or TRANCE). Because inhibition of
osteoclastogenesis is one of the main mechanisms by which estrogen (E2) prevents bone
loss, it is likely that E2 may regulate either the production of, or the target cell
responsiveness to RANKL. We found that E2 decreases the differentiation into OC of both …