[HTML][HTML] Early postnatal cardiac changes and premature death in transgenic mice overexpressing a mutant form of serum response factor
X Zhang, J Chai, G Azhar, P Sheridan… - Journal of Biological …, 2001 - ASBMB
Serum response factor (SRF) is a key regulator of a number of extracellular signal-regulated
genes important for cell growth and differentiation. A form of the SRF gene with a double
mutation (dmSRF) was generated. This mutation reduced the binding activity of SRF protein
to the serum response element and reduced the capability of SRF to activate the atrial
natriuretic factor promoter that contains the serum response element. Cardiac-specific
overexpression of dmSRF attenuated the total SRF binding activity and resulted in …
genes important for cell growth and differentiation. A form of the SRF gene with a double
mutation (dmSRF) was generated. This mutation reduced the binding activity of SRF protein
to the serum response element and reduced the capability of SRF to activate the atrial
natriuretic factor promoter that contains the serum response element. Cardiac-specific
overexpression of dmSRF attenuated the total SRF binding activity and resulted in …