[HTML][HTML] Overexpression of epidermal growth factor induced hypospermatogenesis in transgenic mice
RWC Wong, RWP Kwan, PHS Mak, KKL Mak… - Journal of Biological …, 2000 - ASBMB
The in vivo role of epidermal growth factor (EGF) is not well defined even though its effects
on culture cells were well studied. To understand the developmental, physiological, and
pathological roles of EGF, we have generated transgenic mice widely expressing human
EGF with the use of the β-actin promoter. EGF and transforming growth factor α (TGFα) bind
with equal affinity to the EGF receptor, a transmembrane tyrosine kinase, to trigger various
biological responses. EGF and TGFα signaling are implicated in the development of the …
on culture cells were well studied. To understand the developmental, physiological, and
pathological roles of EGF, we have generated transgenic mice widely expressing human
EGF with the use of the β-actin promoter. EGF and transforming growth factor α (TGFα) bind
with equal affinity to the EGF receptor, a transmembrane tyrosine kinase, to trigger various
biological responses. EGF and TGFα signaling are implicated in the development of the …