Cyclin and cyclin-dependent kinase expression in the remnant glomerulus.
SJ Shankland, P Hamel… - Journal of the American …, 1997 - journals.lww.com
Recent studies suggest that subtotal renal ablation is associated with an early phase of
mesangial cell proliferation. Because the mechanism (s) responsible for this response have
not been elucidated, the study presented here sought to determine if changes in expression
of positive cell cycle regulators, including pRb, cyclin E, and cdk2, occurred in the
glomerulus during the early period of compensatory renal hypertrophy that follows 5/6 renal
ablation. A first group of rats underwent sham operation and served as the control group. A …
mesangial cell proliferation. Because the mechanism (s) responsible for this response have
not been elucidated, the study presented here sought to determine if changes in expression
of positive cell cycle regulators, including pRb, cyclin E, and cdk2, occurred in the
glomerulus during the early period of compensatory renal hypertrophy that follows 5/6 renal
ablation. A first group of rats underwent sham operation and served as the control group. A …