Interleukin 2 receptors
M Allouche, Y Sahraoui, Y Augery-Bourget… - Leukemia research, 1990 - Elsevier
Abstract Interleukin 2 receptors (IL-2-R) are composed of (at least) two chains: the α chain
(or p55 or Tac) and the β chain (or p70 or p75). The association of both chains constitutes
high affinity IL2-R complexes (K d⋍ 10–100 pM), whereas the α-chain or the β chain alone
bind IL-2 with low (K d⋍ 5–50 nM) and intermediate (K d⋍ 1 nM) affinities, respectively. The
β chain (but not the α chain) mediates IL-2 internalization and signal transduction
(proliferation or differentiation) to the cell, thus only high and intermediate affinity IL-2-R are …
(or p55 or Tac) and the β chain (or p70 or p75). The association of both chains constitutes
high affinity IL2-R complexes (K d⋍ 10–100 pM), whereas the α-chain or the β chain alone
bind IL-2 with low (K d⋍ 5–50 nM) and intermediate (K d⋍ 1 nM) affinities, respectively. The
β chain (but not the α chain) mediates IL-2 internalization and signal transduction
(proliferation or differentiation) to the cell, thus only high and intermediate affinity IL-2-R are …